Each 5ML contains;
Racecadotril ………………. 10 mg
Acute diarrhea in children and adults
Chronic HIV-associated diarrhea in adults
DOSE AND ADMINISTRATION
CHILDREN [aged 2months to 2 years] with severe diarrhea:
Day 1 – The usual daily dose is decided according to the body weight on the basis of 1.5 /kg per dose, with a dose given immediately and then three more doses divided in the day
OR 6mg/kg/day in divided doses.
Day 2 onwards -1.5mg/kg [per dose] three times daily.
Dosage (1.5mg/kg body weight)
2 month to 1 year
|2 to 10 kgs||3 mg to 15 mg|
1 yr to 2. 5 years
|10 kg to 12kg||15mg to 18mg|
2.5 yrs to 9 years
|12 kg to 28kg||1 8 mg to 42 mg|
Racecadotril is the first and only enkephalinase inhibitor in its class. The enkephalins act as neurotransmitters in the gastrointestinal tract by activating delta-opiate receptors and thus reducing the level of cyclic AMP. The result is reduced secretion of water and electrolytes into the intestinal lumen without any detectable effect on intestinal motility. Racecadotril has antisecretory actions only when hypersecretion is present, and not in the basal state
Racecadotril is contraindicated in patients with known hypersensitivity to any of the ingredients of the formulation.
Some cases of sleepiness were reported during the clinical trials. Nausea, vomiting, constipation, dizziness and migraine were rarely reported.
The side effects were mild and natural, frequency and intensity being equivalent to that of those reported with placebo.
30 ml bottle of suspension with measuring cap
60 ml bottle of suspension with measuring cap